By Nancy E. Lane (auth.), Nancy E. Lane (eds.)
In Aids hypersensitive reaction and Rheumatology, scientific specialists survey the most recent details to be had at the key rheumatic and allergic matters that physicians face in treating the HIV-infected sufferer. Their articles concentrate on the rheumatologic and dermatologic manifestations of HIV-1 an infection, which come with arthritis, myopathies, vasculitis, sicca syndrome, different autoimmune phenomena, and psoriasis. additionally they research the query of allergy symptoms in HIV sufferers, together with drug hypersensitive reaction, with detailed awareness given to adversarial reactions to trimethoprim-sulfamethoxazole, the main often prescribed anti-infective. functional suggestion for the prognosis and therapy of those difficulties is given in complete.
Aids hypersensitive reaction and Rheumatology deals physicians a entire consultant to the analysis and remedy of the allergic, immunologic, and rheumatic issues in HIV sufferers. Authoritative and practice-oriented, the ebook is destined to develop into a typical source for all these treating AIDS sufferers today.
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Extra info for AIDS Allergy and Rheumatology
29,94-105. 29. , Deam, D. R, and MacKay, I. R (1987), Am. J. Clin. Pathol. 88, 348-351. 30. Ng, V. , Chen, K. , Hwang, K. , and McGrath, M. S. (1989), Blood 74, 2471-2475. 31. Ng, V. , Hwang, K. , Reyes, G. R, Kaplan, L. , Hadley, W. , and McGrath, M. S. (1988), Blood 71,1397-1401. 8-L ymphocytes and Autoantibodies 27 32. , Veronese, M. , and Chieco-Bianchi, L. (1990), AIDS Res. Hum. Retroviruses 6,581-586. 33. Konrad, R. J, Kricka, L. J, Goodman, D. B. P. , and Silberstein, L. E. (1993), N. Eng/.
Consequently, patients presenting to a physician with Reiter's syndrome or reactive arthritis should be questioned about HIV risk factors, such as sex with other males, unprotected sex with many partners, iv drug abuse, and blood transfusions. Seventy-three percent of HIV-infected individuals with Reiter's syndrome from North America are HLA-B27 positive, a proportion similar to that found in idiopathic Reiter's syndrome (2). In contrast, HLA-B27 has not been detected in any of 13 Black patients with Reiter's syndrome and HIV infection (12,13), possibly reflecting either the low prevalence of HLA-B27 in Blacks in general and in Black patients with Reiter's syndrome in particular, or different causative agents or mechanisms in Black patients (2).
Digital ischemia with frank gangrene, other skin lesions, and evidence of gastrointestinal involvement on rectal biopsy have also been noted. Hepatitis B surface antigen was not detected in five HIV-infected individuals with polyarteritis nodosa-like syndromes who were tested for this antigen (2,103). Pathologically, the patients with HIV-associated polyarteritis nodosa-like syndromes resemble typical polyarteritis nodosa with necrotizing vasculitic lesions of medium-sized vessels. These histologic Rheumatologic Manifestations 45 findings have been most commonly demonstrated in small muscular arteries within muscles, as well as epineural arteries and arterioles.