By Valerie Walker, J. D. Pickard (auth.), L. Symon, J. Brihaye, B. Guidetti, F. Loew, J. D. Miller, H. Nornes, E. Pásztor, B. Pertuiset, M. G. Yaşargil (eds.)
As an addition to the ecu postgraduate education process for younger neurosurgeons we started to post in 1974 this sequence dedicated to Advances and Technical criteria in Neurosurgery which used to be later subsidized through the eu organization of Neurosurgical Societies. the truth that the English language is definitely that allows you to turning into the overseas medium at eu clinical meetings is a brilliant asset by way of mutual knowing. for that reason we've determined to submit all contributions in English, whatever the local language of the authors. All contributions are submitted to the total editorial board earlier than booklet of any quantity. isn't meant to compete with the courses of unique Our sequence clinical papers in different neurosurgical journals. Our purpose is, really, to offer fields of neurosurgery and comparable parts within which vital contemporary advances were made. The contributions are written through experts within the given fields and represent the 1st a part of each one quantity. within the moment a part of every one quantity, we submit exact descriptions of normal operative systems, supplied by means of skilled clinicians; in those articles the authors describe the concepts they hire and clarify the benefits, problems and hazards serious about a number of the systems. This half is meant essentially to aid younger neurosurgeons of their submit graduate education. even if, we're confident that it'll even be helpful to skilled, totally informed neurosurgeons.
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Extra info for Advances and Technical Standards in Neurosurgery: Volume 2
X . 10 · S 100 m . 2 ·99 c • - 68 '6 r . x =16·6 o 5'0 Pa CO. ,. ------- -----~---~---------~---~ 5'0 6 '0 Pa 6'0 C02 (mm Hgl Fig. 5. Effect of indomethacin on the response ofCBF to CO 2 in the anaesthetized baboon (from Pickard 1981, with permission) anaesthesia (Fujishima et al. 1971, Grubb et al. 1974, Dahlgren and Siesjo 1981), together with the semiquantitative heat-clearance method employed, might explain the failure of Cuypers et al. (1978) to observe any cerebrovascular effects with indomethacin.
1983, Wieloch et al. 1983). In the goat, both indomethacin and ibuprofen reduced CBF as measured with an electromagnetic flowmeter on the internal maxillary artery, but they did not reduce the effect of hypercapnia (Hoffman et al. 1982). The original paradoxical observation ofCrockard et al. (1982) that 1N-butylimidazole, a potent inhibitor of thromboxane synthetase, mimics the effects of indomethacin on the cerebral circulation in the gerbil has been confirmed by Sofeir et al. (1983) in the rabbit, where a large dose of 25 mg/kg i.
In cerebral arteries from various species, calcium antagonists are much more effective than calciumfree medium in suppressing the contractile effect ofPGFzu and carbocyclic TXA z (Brandt 1981, Towart and Perzborn 1981, Toda 1982, Uski 1984). Uski's explanation is that calcium-free medium in the absence of a high concentration of chelating agent such as EGTA does not remove all the extracellular-bound calcium which is still in a form that can be used by membrane calcium channels. However, such channels are blocked by calcium antagonists, hence the disparity.